Saturday, July 24, 2010

A new study finds that African ancestry is linked to triple-negative breast cancer, a more aggressive type of cancer that has fewer treatment options

Researchers found that, among women with breast cancer, 82% of African women were triple negative, 26% of African-Americans were and 16% of white Americans were. Triple negative breast cancer is negative for three specific markers that are used to determine treatment: the estrogen receptor, the progesterone receptor and HER-2/neu. Researchers found that Ghanaian women were diagnosed at a younger age than American women, and with larger tumors and more advanced cancer. In addition, the Ghanaian women were more likely to test negative for each of the three markers. Prior studies have shown that while African-American women are less likely than white women to develop breast cancer, those who are diagnosed are usually younger and are more likely to die from the disease. These characteristics, including the triple negative disease, are also more common among women with a known hereditary predisposition for breast cancer related to BRCA1 gene mutations. Other studies have also shown a hereditary breast cancer risk associated with racial-ethnic identity - most commonly among Ashkenazi Jewish women.

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